Cellular and Molecular Mechanisms of Fungal Infection Pathogenesis and Therapy

Grant number: 1069284 | Funding period: 2014 - 2016

Completed

Abstract

Fungal infections are serious problems for patients with depressed immunity such as chemotherapy or transplant patients. More effective antifungal treatments are needed. We will study a model of fungal infection in zebrafish embryos that recapitulates human penicilliosis. The research will study how the infection establishes and how different types of white blood cells either help or hinder infection establishment. The results will point to new approaches for treating serious fungal infections.

Related publications (3)

Β-Glucan–dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment

V Pazhakh, F Ellett, BA Croker, JA O’Donnell, L Pase, KE Schulze, R Stefan Greulich, A Gupta, CC Reyes-Aldasoro, A Andrianopoulos, GJ Lieschke

2019-01-01

The initial host response to fungal pathogen invasion is critical to infection establishment and outcome. However, the diversity o..

Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo

F Ellett, V Pazhakh, L Pase, EL Benard, H Weerasinghe, D Azabdaftari, S Alasmari, A Andrianopoulos, GJ Lieschke

2018-06-01

Neutrophils and macrophages provide the first line of cellular defence against pathogens once physical barriers are breached, but ..

A zebrafish model of inflammatory lymphangiogenesis

KS Okuda, JP Misa, SH Oehlers, CJ Hall, F Ellett, S Alasmari, GJ Lieschke, KE Crosier, PS Crosier, JW Astin

2015-01-01

Inflammatory bowel disease (IBD) is a disabling chronic inflammatory disease of the gastrointestinal tract. IBD patients have incr..

University of Melbourne Researchers

Alex Andrianopoulos